Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• polymers can provide gastric protection against gastric-irritating compounds and/or stomach acidity, leading to improved drug release performance. We aimed to fabricate DCS nanocrystals and study their physicochemical and biological properties. The DCS already has great water solubility (Log P = −1.72), so

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• a bioresorbable magnesium alloy stent coated with an anti-proliferative drug, offering a dual benefit of mechanical support and localized drug release, leading to improved outcomes in atherosclerosis treatment [173][174]. Besides, since zinc has emerged as a promising candidate because of its anti

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design

• , magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research. Keywords: drug efficacy; iron oxide nanoparticles; photothermal; solvothermal method; Introduction Cancer is a widespread condition characterized by the

• ., cancer, diabetes, and atherosclerosis), magnetic resonance imaging (MRI), targeted drug delivery, photothermal therapy, gene therapy, and molecular and cellular monitoring [15][16]. Photothermal therapy (PTT), a treatment in which nanostructures are used, induces drug release or damages tumor cells with

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• . After 24, 48, and 72 h, the CHL levels in the NPs were significantly lower when incubated in pH 5.4 medium compared to that in pH 7.4 medium. The faster CHL drug release at pH 5.4 was due to a faster degradation of PLGA at pH 5.4 than that at pH 7.4 [30]. Targeting of nanoparticles to the cells The NPs

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• were observed with cryo-TEM [39]. This technique is widely used to characterize the morphology of nanoemulsions and faithfully confirms the results obtained with other techniques [40]. In vitro drug release One potential advantage of using NEs is their ability to enhance drug solubility and

• ). Our results show that Cym-NE has a k value of 10.4, while Myr-NE has a k value of 3.3. A higher k value indicates faster drug release, while a lower k value indicates slower transport kinetics and, consequently, poor drug release from nanocarriers [43]. Furthermore, both Cym-NE and Myr-NE demonstrated

• a transport exponent value (n) of 0.3, indicating a release mechanism primarily driven by Fickian diffusion [44]. The free terpenes exhibited a value of 0.6, suggesting an anomalous transport mechanism for drug release. This mechanism involves a combination of diffusion and dissolution processes for

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• systems, and tissue engineering, according to the requirement of BBR concentration for the desired therapeutic effects. Keywords: antibacterial activity; berberine; drug-release system; electrospun nanofiber; polylactic acid; Introduction Medicinal plants have various biologically active compounds, such

• researchers due to their unique characteristics. First, high porosity and large surface-to-volume ratio of nanofiber scaffolds give the material the potential to be exposed to the biological media for drug release. Besides, 3D nanofiber scaffolds resemble the natural extracellular matrix, promoting nutrients

• and cells to penetrate into their structure [10]. Second, high drug loading can be achieved, and the drug-release profile (i.e., prolonged, stimulus-activated, and biphasic releases) can be modulated by using different nanofiber structures (e.g., blending, core/shell, and multilayer structures) and

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• , modified drug release, prevention of rapid metabolization, protection of photosensitive molecules, the ability to deliver multiple antileishmanial drugs that can have a synergistic effect, and increased solubility, which results in increased bioavailability. These advantages are determined by the

• impact specific drug release kinetics and increase biocompatibility [60]. Different biodegradable polymers have been used for the development of targeted PNPs for the treatment of leishmaniasis [102]. In this scenario, chitosan is an interesting polymer for NP synthesis due to its positive charge, which

• combination therapy. The authors functionalized the surface of PLGA-NPs with Eudragit L30D, a polymer that provides pH-dependent drug release and significantly improved targeted action, thus increasing the efficacy of the drug [45]. Curc-E-PLGA-NPs showed spherical morphology, with a hydrodynamic mean

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• a zero-order kinetic, that means, it constantly releases the encapsulated drug [17]. In opposition, nanospheres are matrix systems formed by polymers without a central core. During the administration, the matrix erodes and the drug diffuses, resulting in a first-order kinetic drug release, that is

• , an exponential drug release [17][20]. Our research found that many articles utilized poly(lactic-co-glycolic acid) (PLGA) and chitosan nanoparticles, especially because they are biocompatible polymers and present great biodegradability. The polymer PLGA is approved for clinical use by Food and Drug

• four weeks postinfection altered the drug release pattern in vitro, were more efficient in reducing worm burden and the amount of eggs in the gut than PZQ alone, and altered the oogram pattern with the predominant presence of dead eggs. In addition, the nanoformulation showed no relevant toxicity in in

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• network, which decreases and prolongs drug release [30]. In vitro interaction of HSA-MPs and CUR-HSA-MPs with cells Cytotoxicity toward tumor cells Cytotoxicity of CUR-HSA-MPs in Huh-7 and MCF-7 cancer cell lines was measured using MTT assay. Notably, HSA-MPs revealed no significant cell death among Huh-7

• to the delayed CUR release from CUR-HSA-MPs enabling long-term drug release, in contrast to the immediate availability of free CUR [40][41]. In the case of slow release rate of MPs, the available CUR concentration is reduced, allowing cells to adapt to stress conditions and thereby showing lower

• particles and tested in vitro to evaluate their effects in the treatment of tumors. The amount of CUR entrapped into protein particles was around 55% to 62%. The drug release profile of microparticles demonstrated a release of approximately 37% CUR in a mixture with 50% ethanol, while in RPMI 7% was

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• circulation time and serum stability. Also, they enable drug release in a sustained and controlled manner [4]. Targeted delivery of drug-loaded NPs can be achieved either through passive targeting, where drugs accumulate in tumor tissues via the enhanced permeability and retention (EPR) effect, or through

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• ) and a biphasic drug release profile with an initial burst release followed by a prolonged phase. The hydrodynamic average diameter and zeta potential of NLC obtained by dynamic light scattering were approximately 150 nm and −13 mV, respectively, while spherical and well-distributed nanoparticles were

• delivering active principles [19]. SLNs comprise a lipid core, solid at 25 °C, stabilized by steric effects with a surfactant. The addition of small amounts of a liquid lipid at 25 °C leads to the improvement of SLNs in terms of sustained drug release and encapsulation efficiency (EE%), enabling the

• oscillation was 12.6 nm for both systems (Figure 7). In contrast with amphiphilic low-weight loading, BNZ is a lipophilic molecule that did not change the structure of the copolymer. Thus, it is proposed to be dissolved in the core of the lipidic nanoparticle. Drug release and physical stability The release

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• properties, drug loading, and drug release are discussed. We highlight the utilization of ethyl cellulose, poly(lactic-co-glycolic acid), and polyurethane/polyurea in the field of nanomedicine as potential drug delivery systems. Advances are still needed to achieve better control over size distribution

• nanomedicine has yielded several relevant advancements since its beginnings in the early 2000s. The dissolution kinetics of poorly soluble drugs have been improved by the production of drug nanocrystals, enabling continuous drug release. Lipid molecular structures have been manipulated at the nanoscale to

• encapsulated in these ethyl cellulose nanoparticles by dissolving it in the hydrophobic droplet phase of the starting nanoemulsions. The drug release from the nanoparticles appeared to follow a coupled diffusion/relaxation model. Nanoemulsions containing ethyl cellulose have also been prepared at room

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• disciplines, such as nanomaterials science, mechanical engineering, pharmacology, and clinical medicine. Nanoparticle (NP)-based therapeutics are uniquely able to improve drug loading efficiency, control drug release, and protect drug molecules against undesired degradation [1][2]. NPs are widely used in

• drug release and photothermal cell killing were realized [78]. Magnetic hyperthermia (MHT) is another hyperthermia strategy, which generates heat under the excitation of a magnetic field [98]. Magnetic NPs have shown promise in diagnosis and therapeutic effects due to their multiple functions (e.g

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• , the pH-responsive linker between HA and PEG is hydrolyzed, leading to the cleavage of the HA layer. This, in turn, decreases the NP size and enables faster tumor diffusion, improved internalization, and drug release at the site of action. These nanocarriers exhibited a high degree of tumor homing, low

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• chromophores, induced by photoirradiation, ultimately decompose the whole nanoarchitecture for drug release. In section 3, various therapeutic nucleic acids are delivered to the target site by CyD nanoarchitectures. By embracing with chemically modified CyDs, otherwise fragile nucleic acids are successfully

• isomerization of azobenzene or its analogues is the most widely employed. CyD-based nanoarchitectures are sufficiently dynamic so that even these subtle molecular changes induce the dissociation of the whole nanoarchitecture for the release of the encapsulated drug. 2.1 Drug release from CyD-based

• opened for the release of encapsulated drug. In order to achieve photoinduced drug release through visible light, tetra-ortho-methoxy-substituted azobenzene (mAzo) can be used instead of unsubstituted azobenzene. The trans-to-cis isomerization of this chromophore proceeds under irradiation with red or

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• mean particle size and zeta potential of the samples in phosphate-buffered saline (PBS) or in RPMI-1640 medium with 10% FBS over a period of 7 days. Samples were collected at specific time points to monitor the changes in particle size and zeta potential. In vitro drug release properties of AB-LNPs The

• interaction between Au-LNPs and BDP. No obvious change of the zeta potentials of AB-LNPs was found in two different media after 7 days (Figure 3b), suggesting that AB-LNPs maintained the nanoparticle structure in PBS and RPMI-1640 + 10% FBS for 7 days. Drug release properties of AB-LNPs To investigate whether

• attributed to the increased solution temperature, which accelerated the dissociation of BDP from AB-LNPs. There are no obvious differences between the release profiles of AB-LNPs at pH 5.5 and at pH 7.4, indicating that AB-LNPs do not exhibit pH-responsive drug release. The stimulus-responsive release

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• charged mucin, decreased pH value, and increased temperature, may provide design clues for mucoadhesive polymeric nanoparticles that have a potential to exhibit higher drug release or help to alleviate colorectal tumor in colon region [11][19][20]. PLGA is a physiologically biocompatible and biodegradable

• polymer approved by the FDA, which can be synthesized as a copolymer of lactic and glycolic acids at various monomer ratios [21]. With its chemical structure suitable for the preparation of nanoparticulate drug delivery systems and its polymeric structure suitable for drug release profile designs, it is

• preserve a DCX amount of about 60% and a substantial amount of DCX was released at the colonic pH values. It is known that surface modification with CS provides a prolonged drug release profile to NP [51][52]. In vitro evaluation of nanoparticle interaction with mucus Orally administered drug molecules

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• advantage of soluble inserts is that they do not have to be removed from the eye. The rate of drug release is influenced by dissolution or erosion of the polymer matrix. Ophthalmic therapeutic systems belong to the group of non-biodegradable inserts from which the drug substance is released by diffusion at

• utilized not only as drug delivery systems but also as minimally invasive diagnostic tools [145][146]. The advantages of hydrogel-forming systems include relatively high drug-loading capacity and the possibility to modify the drug release rate with respect to the individual needs, which is usually achieved

• scaffold to increase the matrix stability and to provide prolonged drug release. It was observed that the patches penetrated the rabbit corneal epidermis without irritation and, after removal, total recovery was observed after 12 h. The developed patch showed great potential as an alternative to ocular

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• delivery system in synthetic bone implants can stimulate bone regeneration while preventing bacterial infection. Furthermore, coating materials containing TiO2 can help drug stabilisation producing a long-term drug release profile [119]. The electrochemical anodization process was used by Lai et al. (2018

• -linking methods. Next, vancomycin hydrochloride was encapsulated into the microspheres. In vitro biomineralisation tests show apatite formation on the surface of the microspheres. In addition, a sustainable drug release profile was detected. This finding reveals that the produced microspheres have

Spindle-like MIL101(Fe) decorated with Bi₂O₃ nanoparticles for enhanced degradation of chlortetracycline under visible-light irradiation

• Chen-chen Hao,
• Fang-yan Chen,
• Kun Bian,
• Yu-bin Tang and
• Wei-long Shi

Beilstein J. Nanotechnol. 2022, 13, 1038–1050, doi:10.3762/bjnano.13.91

• cavities, and excellent thermal stability [20][21]. These advantages make it appalling to adsorption [22], gaseous capture/separation [23], sensing [24], and drug release applications [25]. Moreover, some MOFs can be excited under UV or visible light and exhibit light harvesting properties due to ligand

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• optimal treatment. Therefore, the characteristics of nanoparticles regarding mechanical properties, size, surface charge, surface composition, and degradation and drug release mechanisms must be considered during formulation development [1]. Except for the mechanical properties, the research activities do

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• kept in the skin for a longer period of time and penetrate into deeper layers. In a study by Fathalla et al., the gel-based formulations tested, especially with the ETH-based gel system, showed prolonged drug release in the treatment and yielded more successful results in the permeation study in rats

• anthralin against psoriasis and reduce its side effects, various liposomal and ethosomal formulations were prepared with different compositions and characterized in terms of drug encapsulation efficiency, size, and morphology. The determined optima formulations were distributed on various gel bases and drug

• release kinetics were investigated. The formulations used had PSs in the nanoscale range and drug encapsulation efficiency values were over 97.2% and 77% [34]. In our study, both the ETHs and ETHG systems have been proven to be effective and safe in treatments with the cell permeation rate and

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• an ideal drug loading capacity (38.44%) and prolonged drug release [69]. The results showed that the curcuminoid-loaded HA-CNPs suppressed the NF-kB pathway and decreased the expression of MMP-1 and MMP-13 while increasing the expression of type-II collagen in a knee OA chondrocyte model. Furthermore

Effects of drug concentration and PLGA addition on the properties of electrospun ampicillin trihydrate-loaded PLA nanofibers

• Tuğba Eren Böncü and
• Nurten Ozdemir

Beilstein J. Nanotechnol. 2022, 13, 245–254, doi:10.3762/bjnano.13.19

• concentration (4–12%) and addition of PLGA (20–80%) on the spinnability of the solutions, morphology, average nanofiber diameter, encapsulation efficiency, drug release, and mechanical properties of PLA and PLA/PLGA nanofibers were examined. All nanofibers were bead-free and uniform. They had favorable

• encapsulation efficiency (approx. 90%) and mechanical properties. The increase in the amount of ampicillin trihydrate caused an increase in the diameter and burst effect of the nanofibers. The drug release ended on the 7th and 3rd day with nanofibers containing 4% and 12% of drug, respectively. The prolonged

• and controlled drug release for ten days was obtained with nanofibers containing 8% of drug. Thus, the ideal drug concentration was determined to be 8%. Nanofibers containing PLA/PLGA had a larger diameter than those including PLA. In addition, both the strength and elongation of nanofibers decreased

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• delivery. Ideal drug delivery systems encompass two elements, that is, the control over drug release and the ability to target specific locations in order to reduce systemic toxicity and undesirable side effects. Porous TiO2 has shown tremendous ability to sustain a concentration of drugs within the

• demonstrated enhanced osseointegration [58]. Additionally, drug release kinetics and duration from titania nanotubes (TNTs) can be controlled by modifying nanotube dimensions, surface chemistry, or by a polymer coating on the TNT implant surface through dip coating or plasma polymerization. Losic and co

• augmenting better attachment of drug molecules, and the drug release profile was extended to more than 15 days by minimizing the burst release effect [59]. Polycaprolactone is a semi-crystalline biodegradable polymer used as a drug carrier, packaging material, and 3D scaffold for bone tissue engineering